We’ve developed and validated a TMS/fMRI setup which allows us to manipulate and measure brain activity at the same time by combining Transcranial Magnetic Stimulation (TMS) with functional Magnetic Resonance Imaging (fMRI). A dedicated MR coil array allows for high-sensitivity fMRI, particularly at the site of stimulation. Contrary to the standard birdcage approach, this coil has excellent imaging quality at the stimulation site; and due to its flexibility, the new coil can be easily combined with neuronavigation within the MR scanner to allow for accurate targeting in TMS/fMRI experiments.
This dedicated MR coil array is distributed via Magventure. It is compatible with the MRi-B91 coil, MagPro stimulator and can be combined with current neuronavigation systems.
Navarro de Lara L¹, Tik M¹, Woletz M, Frass-Kriegl R, Moser E, Laistler E, Windischberger C. High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil. NeuroImage. 2017 Apr 15;150:262-9.
Tik M, Woletz M, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Mapping TMS local and remote immediate effects by concurrent TMS/fMRI using a dedicated high-sensitivity coil array. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. 2017 Mar 1;10(2):489-91.
Tik Martin, Woletz Michael, Navarro de Lara L, Sladky R, Hoffmann A, Hummer A, Windischberger C. Multimodal assessment of TMS-induced acute effects. 22nd Meeting of the Organization for Human Brain Mapping, HBM – Geneva, 2016.
Navarro de Lara L, Tik M, Woletz M, Bukowski H, Stürkat IL, Lamm C, Moser E, Windischberger C. . Boosting the sensitivity of concurrent TMS/fMRI in motor cortex using a dedicated MR coil array. 21th Meeting of the Organization for Human Brain Mapping, HBM – Honolulu, 2015.
Navarro de Lara L, Windischberger C, Kuehne A, Woletz M, Sieg J, Bestmann S, Weiskopf N, Strasser B, Moser E, Laistler E. A novel coil array for combined TMS/fMRI experiments at 3T. Magn Reson Med. 2014 Nov 24. doi: 10.1002/mrm.25535. PubMed PMID: 25421603. 2014.